By Aart Jan van der Lely, Albert Beckers, Adrian Daly, Steven W. Lamberts, David R. Clemmons
This ebook stories the pathophysiology and actual manifestations of acromegaly and discusses the a number of treatments now to be had for the administration of the sufferer with acromegaly. The publication includes an abundant variety of illustrations that aid to stress issues of specific curiosity, together with radiological, histopathological, and actual analysis photographs. Sections are dedicated to detailing vital subject matters together with determinants of pathological results of ailment job in acromegaly, person healing offerings and standards for analysis, and sickness keep an eye on.
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Extra resources for Acromegaly: Pathology, Diagnosis and Treatment
3. Hosovski E. A case of acromegaly in the Middle Ages. Anthropol Anz 1991; 49(3):273–279. 4. Andolz Canela R. Fermin Arrudi. In: El Gigante Aragone´s. , 1998. 5. Marie P, De Souza-Leite JD. Essays on Acromegaly. London: New Sydenham Society, 1891. 6. Verga A. Caso singolare di prosopectasia. Rend R 1 Limbardo Classe Sc Med Nat 1864; 1:111–117. 7. Brigidi V. Studii anatomo-patologici sopra un uomo divenuto stranamente deforme per cronica infermita. Arch Scuola Anat Patol Firenze 1881; 65–92. 8.
40. Clemmons DR, Van Wyk JJ, Ridgway EC, Kliman B, Kjellberg RN, Underwood LE. Evaluation of acromegaly by radioimmunoassay of somatomedin-C. N Engl J Med 1979; 301:1138–1142. 41. Froesch ER, Burgi H, Ramsier EB, Bally P, Labhart A. Antibody suppressible and nonsuppressible insulin-like activities in human serum and their physiologic significance. An insulin assay with adipose tissue of increased precision and specificity. J Clin Invest 1963; 42:1816–1834. 42. Klapper DG, Svoboda ME, Van Wyk JJ.
The search for these hypothalamic factors led to a race of startling intensity among at least four major research groups, led by Harris in London, Samuel M. McCann in Pennsylvania and later Dallas, Andrew Schally (Fig. 14) in New Orleans, and Roger Guillemin (Fig. 15) in Houston and later San Diego. As described by Nicholas Wade in his book The Nobel Duel (34), both Harris’s and McCann’s teams were pursuing diverse research projects during this period. Schally and Guillemin, however, devoted their time single-mindedly to the identification of a series of hypothalamic releasing factors.