By Roger J. Laham, Donald S. Baim
An interdisciplinary panel of pioneers and opinion leaders evaluation the elemental, preclinical, medical, and developmental pathways to new therapy concepts, corresponding to healing angiogenesis and myogenesis. The authors make the most of new organic knowing, novel healing goals, a number of on hand and well-studied healing techniques, and the required imaging thoughts to degree results. Their in-depth discussions hide the id of latest healing pursuits and pathways, the research of transcriptional elements, grasp change molecules, cell-based methods, chemokines, a greater figuring out of the results of getting older, endothelial disorder, and hypercholesterolemia in keeping with angiogenic stimuli. Highlights contain exam of drug supply difficulties, results degree, stem remedy, high-risk interventions, improvement pathways, and destiny probabilities.
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Additional info for Angiogenesis and direct myocardial revascularization
Development 2000;127:4937–4948. 28. Kuo CT, Veselits ML, Barton KP, Lu MM, Clendenin C, Leiden JM. The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev 1997;11:2996–3006. Chapter 2 / Transcriptional Regulation of Angiogenesis 35 29. Steingrimsson E, Tessarollo L, Reid SW, Jenkins NA, Copeland NG. The bHLHZip transcription factor Tfeb is essential for placental vascularization. Development 1998;125:4607–4616.
The identification of several vascular-specific genes involved in vasculogenesis and the genomic regulatory regions required for directing their expression over the past decade has facilitated the identification of the transcriptional mechanisms required for vascular-specific gene expression. Targeted disruption of additional transcription factors that have been associated with vascular defects led to the elucidation of a role for these factors in vascular development. Angiogenesis, the development of additional blood vessels from a primary vascular network, may recapitulate many of the molecular events occurring during vascular development.
Secondary issues influencing the model selection are experimental goals, available expertise/equipment/technology, and the study budget. An ideal animal model for angiogenesis studies should have the following characteristics (1): 1. 2. 3. 4. Small, yet easily implemented and maintained Coronary anatomy and innate collateral circulation similar to humans Collateral development in the virtual absence of infarction Consistent, regional abnormalities in left-ventricular (LV) perfusion and function 5.